Ribosomes and protein synthesis.
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Ribosomes and protein synthesis
Let us start at the very beginning. Between 1897 and 1899, G. Gamier, in France, published elegant microscope studies describing a basophilic component ofthe cytoplasm of glandular cells (1) . Because of what he thought its role might be in the elaboration and transformation of secretory products, he gave a Greek name to these concepts-ergastoplasm (work plasm) . Gamier's research was extended ...
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The ribosome is universally responsible for synthesizing proteins by translating the genetic code transcribed in mRNA into an amino acid sequence. Ribosomes use cellular accessory proteins, soluble transfer RNAs, and metabolic energy to accomplish the initiation, elongation, and termination of peptide synthesis. In translocating processively along the mRNA template during the elongation cycle, ...
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The Biochemical Society's Forty-Seventh Symposium, held in London in December 1981, assembled some of the leading workers in this area of biochemistry. The subjects for discussion were chosen for their timeliness and distinctiveness, and included accounts of ribosome and messenger RNA structure and function, initiation factors, caps and ribonucleoproteins, as well as consideration of the proces...
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In a purified system containing poly(U) and ribosomal subunits from Escherichia coli, and purified transfer factors T and G, the active ribosomal complex passes through a cycle of contraction and expansion with the addition of each amino acid; aminoacyl-tRNA binding catalyzed by T produces the stable compact state, corresponding to the 70S conformation, whereas translocation with G expands the ...
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Using image reconstruction methods, electron microscopists can now visualize ribosomes at resolutions so high that the changes in the positions of ribosome-bound tRNAs which occur during protein synthesis can be seen.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1981
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.91.3.53s